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Updated: Mar 23, 2026

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model
Published on: October 20, 2023
Genetically Dissecting Cortical Neurons Involved in Epilepsy in Angelman Syndrome
Emanuela Santini1, Eric Klann1
1Center for Neural Science, New York University, New York, NY 10003, USA.
Abstract:
Epilepsy in Angelman Syndrome is thought to originate from an imbalance between local excitatory-inhibitory circuits that results in a generalized hyperexcitability. In this issue of Neuron, Judson et al. (2016) demonstrate that selective maternal deletion of Ube3a in cortical GABAergic neurons causes circuit hyperexcitability, increased seizure severity, and EEG abnormalities.
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