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Updated: Mar 23, 2026
Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
Biointerface by Cell Growth on Graphene Oxide Doped Bacterial Cellulose/Poly(3,4-ethylenedioxythiophene) Nanofibers
Chuntao Chen1, Ting Zhang2, Qi Zhang3,2
1Institute of Chemicobiology and Functional Materials, School of Chemical Engineering, Nanjing University of Science and Technology , 200 Xiao Ling Wei Street, Nanjing, Jiangsu Province, China.
Abstract:
Highly biocompatible advanced materials with excellent electroactivity are increasingly meaningful to biointerfaces and the development of biomedicine. Herein, bacterial cellulose/poly(3,4-ethylene dioxythiophene)/graphene oxide (BC/PEDOT/GO) composite nanofibers were synthesized through the in situ interfacial polymerization of PEDOT with the doping of GO. The abundant free carboxyl and hydroxy groups offer the BC/PEDOT/GO film active functional groups for surface modification. We demonstrate the use of this composite nanofiber for the electrical stimulation of PC12 neural cells as this resultant nanofiber scaffold could closely mimic the structure of the native extracellular matrix (ECM) with a promoting cell orientation and differentiation after electrical stimulation of PC12 cells. It is expected that this biocompatible BC/PEDOT/GO material will find potential applications in biological and regenerative medicine.
