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Published on: March 10, 2023
A near-infrared AIEgen for specific imaging of lipid droplets
Miaomiao Kang1, Xinggui Gu, Ryan T K Kwok
1Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration & Reconstruction, Institute for Advanced Study, Division of Biomedical Engineering, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. tangbenz@ust.hk.
Abstract:
A new near-infrared AIE luminogen (TPE-AC) with high specificity, good biocompatibility and excellent photostability is designed and synthesized for lipid droplet (LD) imaging in cells. TPE-AC can monitor the process of LD accumulation in cells, thus making it potential for the diagnosis of early-stage fat-related diseases.
