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Minimal Erythema Dose MED Testing

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Published on: May 28, 2013

Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures.

Carolyn J Steber¹, Scott L Perkins², Kira B Harris¹

¹Levine College of Health Sciences, Wingate University, Wingate, NC, USA.

The American Journal of Case Reports

|April 9, 2016

Summary

Metformin can cause fixed-drug eruptions (FDEs), a type of skin reaction. This case report highlights the importance of recognizing FDEs associated with this common diabetes medication.

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Area of Science:

Dermatology
Pharmacology

Background:

Fixed-drug eruptions (FDEs) are characterized by recurrent cutaneous lesions upon re-exposure to a specific drug.
While several drugs are commonly implicated, any medication can potentially trigger an FDE.
Metformin, a widely prescribed antidiabetic drug, has limited documented association with FDEs.

Observation:

A 56-year-old woman presented with recurrent, round, erythematous lesions on her palms and soles.
These lesions consistently appeared after metformin exposure and resolved upon drug discontinuation.
The Naranjo scale indicated a definite association between metformin and FDE in this patient.

Findings:

This case report adds to the scarce literature on metformin-induced fixed-drug eruptions.
The patient experienced characteristic FDE lesions attributed to metformin use.

Implications:

Clinicians should consider metformin as a potential cause of FDEs in patients presenting with suggestive skin lesions.
Increased awareness of metformin-associated FDEs is crucial for accurate diagnosis and management.