Related Experiment Video

Updated: Mar 22, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

16.6K

(Dicer)phering roles of microRNA in platelets

Eric Boilard1, Clémence Belleannée1

  • 1CENTRE DE RECHERCHE DU CENTRE HOSPITALIER UNIVERSITAIRE DE QUÉBEC.

Blood
|April 9, 2016
PubMed

Insights

Noncoding RNAs precisely control messenger RNA (mRNA) levels in platelets. Modifying this regulation in mice impacts platelet function in hemostasis and thrombosis.

Area of Science:

  • Molecular Biology
  • Hematology
  • RNA Biology

Background:

  • Platelets play a critical role in hemostasis and thrombosis.
  • The molecular mechanisms governing platelet function are complex and not fully understood.
  • Noncoding RNAs are increasingly recognized for their regulatory roles in cellular processes.

Purpose of the Study:

  • To investigate the role of noncoding RNAs in regulating the messenger RNA (mRNA) profile of platelets.
  • To determine the impact of interfering with noncoding RNA regulation on platelet function.

Main Methods:

  • Utilized genetically engineered mouse models.
  • Analyzed platelet mRNA profiles.
  • Assessed hemostatic and thrombotic functions in modified mice.

Main Results:

  • Noncoding RNAs were found to precisely regulate the mRNA content of platelets.
  • Genetic interference with noncoding RNA regulation altered platelet mRNA profiles.
  • Hemostatic and thrombotic functions of platelets were significantly affected by these alterations.

Conclusions:

  • Noncoding RNAs are key regulators of platelet mRNA profiles.
  • Targeting noncoding RNA pathways could modulate platelet function.
  • This finding opens new avenues for understanding and potentially treating platelet-related disorders.

More Related Videos

Microfluidics in Assessing Platelet Function06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K
Ferric Chloride-induced Murine Thrombosis Models10:37

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

23.4K

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

12.0K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.5K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.8K