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A simple practice guide for dose conversion between animals and human.

Anroop B Nair1, Shery Jacob2

  • 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia.

Journal of Basic and Clinical Pharmacy
|April 9, 2016
PubMed
Summary
This summary is machine-generated.

This review explains interspecies allometric scaling for converting animal doses to human equivalent doses. It aids pharmaceutical researchers in estimating starting doses for clinical trials and calculating injection volumes.

Keywords:
Calculationclinical trialsexperimentextrapolationparenteralspeciesstarting dosetranslation

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Area of Science:

  • Pharmacology
  • Drug Development
  • Biomedical Research

Background:

  • Dose extrapolation between species is crucial for pharmaceutical research.
  • Interspecies allometric scaling for dose conversion is a complex and debated topic in clinical pharmacology.
  • This method accounts for body surface area differences related to animal weight.

Purpose of the Study:

  • To provide fundamental information on translating doses between species.
  • To explain the estimation of initial clinical trial doses using allometric scaling.
  • To briefly outline the calculation of injection volumes for parenteral formulations based on human equivalent dose.

Main Methods:

  • Review of allometric scaling principles.
  • Explanation of dose translation methodologies.
  • Description of human equivalent dose calculation.

Main Results:

  • Allometric scaling utilizes body surface area to extrapolate doses across species.
  • Provides a framework for estimating safe and effective starting doses in human trials.
  • Offers guidance on parenteral formulation injection volume calculations.

Conclusions:

  • Allometric scaling is an important tool for pharmaceutical researchers.
  • Understanding dose extrapolation aids in the design of animal and human studies.
  • This review simplifies the application of allometric scaling in drug development.