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MAF drives CD8+ T-cell exhaustion
1Department of Oncology and Ludwig Cancer Research Center, University of Lausanne , Biopole 3, Ch. des Boveresses 155 , Epalinges, Switzerland.
Oncoimmunology
|April 9, 2016
Abstract:
The molecular regulation of tumor induced T-cell exhaustion remains poorly characterized. Recently, we compared the transcriptome of "exhausted" CD8+ T cells infiltrating melanomas to those of naive and acutely stimulated CD8+ T cells. We demonstrated that MAF is over-expressed and plays a key role in driving the transcriptional program of T-cell exhaustion.
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