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Gold-Catalyzed Anti-Markovnikov Selective Hydrothiolation of Unactivated Alkenes
Taichi Tamai1, Keiko Fujiwara1, Shinya Higashimae1
1Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University , 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531, Japan.
Abstract:
Despite the widespread use of transition-metal catalysts in organic synthesis, transition-metal-catalyzed reactions of organosulfur compounds, which are known as catalyst poisons, have been difficult. In particular, the transition-metal-catalyzed addition of organosulfur compounds to unactivated alkenes remains a challenge. A novel gold-catalyzed hydrothiolation of unactivated alkenes is presented, which proceeds effectively to give the anti-Markovnikov-selective adducts in good yields and in a regioselective manner.
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