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Updated: Mar 22, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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Published on: November 28, 2015

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PRG3 induces Ras-dependent oncogenic cooperation in gliomas.

Zheng Fan1, Philipp Bittermann-Rummel1, Eduard Yakubov1,2

  • 1Translational Neurooncology Laboratory, Department of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.

Oncotarget
|April 9, 2016
PubMed
Summary

The neuronal gene PRG3 promotes malignant glioma growth by cooperating with Ras signaling. Dysregulated PRG3 levels enhance tumor proliferation and invasion, worsening patient outcomes.

Keywords:
PRG3Rasgliomaneuronal plasticityoncogenesis

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