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Resveratrol and Ophthalmic Diseases.
Khaled K Abu-Amero1,2, Altaf A Kondkar3, Kakarla V Chalam4
1Department of Ophthalmology, University of Florida College of Medicine, FL 32209, USA. abuamero@gmail.com.
Nutrients
|April 9, 2016
Summary
Resveratrol, found in grapes, offers antioxidant and anti-inflammatory benefits for eye health. Research suggests its potential to combat age-related vision loss by targeting key disease pathways.
Area of Science:
- Ophthalmology
- Nutritional Science
- Pharmacology
Background:
- Resveratrol, a polyphenol from grapes, exhibits antioxidant and anti-inflammatory properties.
- Age-related ocular diseases like glaucoma and macular degeneration are linked to oxidative stress and inflammation.
- These conditions cause progressive vision loss and blindness.
Purpose of the Study:
- To review the scientific literature on resveratrol's effects on age-related eye disorders.
- To explore resveratrol's mechanisms of action in ocular disease pathogenesis.
- To assess resveratrol's potential as a nutritional therapeutic for eye conditions.
Main Methods:
- In vitro and in vivo experimental studies were analyzed.
- Literature review focusing on resveratrol's impact on oxidative stress, inflammation, and mitochondrial dysfunction.
- Examination of pathways including apoptosis, pro-survival, and angiogenesis relevant to ocular diseases.
Main Results:
- Resveratrol demonstrates protective effects against oxidative stress and inflammation in ocular tissues.
- Experimental studies indicate resveratrol influences multiple pathways implicated in age-related eye diseases.
- Evidence suggests potential benefits for glaucoma, cataracts, diabetic retinopathy, and macular degeneration.
Conclusions:
- Resveratrol shows promise as a therapeutic agent for age-related eye diseases.
- Further research is needed to establish optimal use and limitations as a nutritional intervention.
- Resveratrol's multifaceted action warrants continued investigation for vision preservation.
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