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Updated: Mar 22, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
Published on: April 22, 2021
SMITten by the Speed of Splicing
Tracy L Johnson1, Manuel Ares2
1Molecular, Cell, and Developmental Biology, Terasaki Life Sciences Building Room 5159, 610 Charles Young Drive East, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Abstract:
Splicing occurs co-transcriptionally, but relative rates of splicing and transcription that might reveal mechanisms of their coordinated control have remained mysterious. Now, Carrillo Oesterreich et al. show that the fastest introns are gone nearly as soon as the 3' splice site is transcribed and that introns have distinct splicing kinetics with respect to polymerase progression along the gene.
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