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Updated: Mar 22, 2026

Mouse Fetal Liver Culture System to Dissect Target Gene Functions at the Early and Late Stages of Terminal Erythropoiesis
Published on: September 9, 2014
EnaBILEing Growth in the Fetal Liver
Wolfram Goessling1, Trista E North2
1Genetics and Gastroenterology Divisions, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Abstract:
Blood stem cells develop at successive sites in the vertebrate embryo, but the functional explanation for this behavior is unknown. Sigurdsson et al. (2016) provide justification for transient fetal liver residence, where select bile acid composition, derived from mother and embryo, provides a protective environment, enabling rapid stem cell expansion.
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