Dietary flavonoid fisetin for cancer prevention and treatment

Area of Science:

• Biochemistry
• Oncology
• Nutritional Science

Background:

• Cancer is a leading global cause of death, driving research into novel prevention and treatment strategies.
• Dietary flavonoids are increasingly investigated for their potential anticancer properties due to safety and accessibility.
• Fisetin, a naturally occurring flavonoid, has demonstrated preclinical anticancer effects.

Purpose of the Study:

• To review the chemopreventive and therapeutic potential of fisetin against various cancers.
• To elucidate the molecular targets and mechanisms underlying fisetin's anticancer activity.
• To highlight the need for human clinical trials to validate preclinical findings.

Main Methods:

• Literature review of in-vitro and in-vivo studies on fisetin's anticancer effects.
• Analysis of research on fisetin's impact on cancer cell cycle, apoptosis, angiogenesis, invasion, and metastasis.
• Examination of studies investigating fisetin's molecular targets and mechanisms of action.

Main Results:

• Preclinical studies indicate fisetin inhibits cancer growth by modulating cell cycle, inducing apoptosis, and affecting angiogenesis, invasion, and metastasis.
• Fisetin has shown efficacy against various cancers in preclinical models without apparent toxicity to normal cells.
• Established molecular targets and mechanisms contribute to fisetin's observed anticancer activity.

Conclusions:

• Fisetin exhibits significant chemopreventive and therapeutic potential against cancer based on preclinical evidence.
• Understanding fisetin's molecular mechanisms provides a basis for developing mechanism-based cancer prevention and treatment strategies.
• Well-designed clinical trials are essential to confirm fisetin's efficacy and safety in human cancer patients.