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[Low Intensity Anticoagulation Therapy for Chinese Population with Heart Valve Replacement--3 000 Cases Follow-up]

Jian-ping Xu, Ying-kang Shi, Li Dong

    Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
    |April 12, 2016
    PubMed

    Insights

    Low-intensity anticoagulation therapy with warfarin, targeting an international normalized ratio (INR) of 1.5-2.5, is safe and effective for Chinese patients with prosthetic heart valves. This approach showed no significant regional differences in efficacy or complications.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Prosthetic heart valves require anticoagulation therapy to prevent thromboembolic events.
    • Optimal anticoagulation intensity in Chinese populations with mechanical heart valves remains an area of investigation.

    Purpose of the Study:

    • To evaluate the safety and efficacy of low-intensity anticoagulation therapy in Chinese patients following heart valve replacement.
    • To determine the optimal target international normalized ratio (INR) range for this patient group.

    Main Methods:

    • A prospective follow-up study of 3,000 patients undergoing heart valve replacement was conducted over one year.
    • Data on anticoagulation methods, intensity (warfarin dosage and INR), and complications were collected and analyzed from two major hospitals.

    Main Results:

    • The study achieved an 88.57% follow-up rate, accumulating 1,726.1 patient-years.
    • The mean INR was maintained within a range of 1.8-2.0, with overall complication and mortality rates of 5.79% and 0.12% per patient-year, respectively.
    • Hemorrhage occurred at 3.59% per patient-year, and thromboembolism at 2.03% per patient-year, with no significant differences between the two participating hospitals.

    Conclusions:

    • An international normalized ratio (INR) range of 1.5-2.5, with a mean of 1.8-2.0, is identified as safe and effective for Chinese patients with prosthetic heart valves.
    • No significant regional variations were observed in the required anticoagulation therapy intensity or complication rates.
    Abstract

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