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Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform
Published on: January 30, 2017
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Determinant molecular markers for peri-gastrulating bovine embryo development
1INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France. Email:
Reproduction, Fertility, and Development
|April 12, 2016
Summary
The peri-gastrulation period is crucial for bovine embryo development and implantation success. This sensitive window, marked by elongation and gastrulation, is vulnerable to biotechnological interventions, impacting pregnancy outcomes.
Area of Science:
- Reproductive Biology
- Developmental Biology
- Animal Science
Background:
- The peri-gastrulation phase, occurring between blastocyst formation and implantation, is critical for bovine conceptus development.
- This period encompasses key events like blastocyst elongation, pregnancy recognition, and uterine secretion, essential for successful pregnancy.
- Early embryo loss and post-implantation mortality are significant issues following assisted reproductive technologies in cattle.
Purpose of the Study:
- To describe the peri-gastrulation period in cattle, focusing on its developmental landmarks.
- To highlight the importance of gastrulation markers, often overlooked compared to elongation markers.
- To question the resilience of these developmental landmarks when exposed to biotechnologies.
Main Methods:
- Literature review and synthesis of existing research on bovine early embryonic development.
- Focus on molecular and cellular interactions between the conceptus and the uterus during peri-gastrulation.
- Analysis of developmental landmarks, including elongation and gastrulation, in the context of assisted reproductive technologies.
Main Results:
- Peri-gastrulation is a sensitive developmental window in cattle, crucial for implantation and subsequent fetal development.
- Elongation markers are commonly used to assess developmental status, but gastrulation markers are equally important due to linked reciprocal interactions.
- Biotechnologies like AI, embryo transfer, and SCNT can disrupt these critical developmental landmarks, leading to embryo loss.
Conclusions:
- The peri-gastrulation period's developmental landmarks are vital for successful bovine reproduction.
- Understanding the interplay between elongation and gastrulation is key to improving outcomes after biotechnological interventions.
- Further research is needed to enhance the resilience of these landmarks against biotechnological challenges and improve pregnancy rates.
