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Organic affective disorder and vascular dysregulation in systemic lupus erythematosus
1College of Physicians and Surgeons, Columbia University, New York, N.Y.
Abstract:
A case is reported in which an exacerbation of systemic lupus erythematosus presented as an organic depressive disorder with psychotic features. Brain imaging using regional cerebral blood flow techniques demonstrated vascular dysregulation in the left frontal lobe of this patient. The implications for understanding the pathogenesis of psychiatric disorders in lupus are discussed.