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Related Concept Videos

Atypical Pneumonia01:14

Atypical Pneumonia

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Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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Related Experiment Video

Updated: Mar 22, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

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Sarcoidosis: An unusual presentation.

Pedro Madureira1, Sofia Pimenta1, Hélder Cardoso2

  • 1Rheumatology Department, Centro Hospitalar de São João, Porto, Portugal; Rheumatology Department, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.

Reumatologia Clinica
|April 13, 2016
PubMed
Summary

This case report details a 35-year-old man with sarcoidosis presenting with arthralgia and purple skin lesions on his hands and feet. Simultaneous involvement of both extremities is a rare manifestation of this specific cutaneous sarcoidosis.

Keywords:
Bone lesionsLesiones óseasLupus pernioSarcoidosis

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Area of Science:

  • Dermatology
  • Rheumatology
  • Internal Medicine

Background:

  • Sarcoidosis is a multisystem inflammatory disease characterized by non-caseating granulomas.
  • Cutaneous sarcoidosis manifests in specific (granulomatous) and nonspecific (non-granulomatous) forms.
  • Lupus pernio is a specific cutaneous manifestation of sarcoidosis, typically affecting the face.

Observation:

  • A 35-year-old man presented with a 3-year history of joint pain and purple discoloration of the skin on his fingers and feet.
  • Radiography revealed cystic bone lesions in the phalanges, and laboratory tests showed elevated liver enzymes.
  • Liver MRI indicated hepatomegaly and retroperitoneal lymphadenopathy.

Findings:

  • Histological analysis confirmed granulomas in skin, lymph nodes, and liver, establishing the diagnosis of sarcoidosis.
  • The patient experienced rapid symptom improvement after initiating prednisolone treatment.
  • This case highlights a rare presentation of lupus pernio affecting both hands and feet simultaneously.

Implications:

  • This case expands the understanding of sarcoidosis's diverse cutaneous manifestations.
  • Simultaneous hand and foot involvement in lupus pernio, though rare, should be considered in the differential diagnosis.
  • Prompt diagnosis and treatment of sarcoidosis can lead to significant symptom relief.