Related Experiment Video

Updated: Mar 22, 2026

Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions
12:23

Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions

Published on: October 13, 2015

9.0K

Yersinia adhesins: An arsenal for infection

Nandini Chauhan1, Agnieszka Wrobel1, Mikael Skurnik2,3

  • 1Evolution and Genetics, Department of Biosciences, University of Oslo, Oslo, Norway.

Proteomics. Clinical Applications
|April 13, 2016
PubMed

Insights

Yersinia bacteria use adhesin molecules for virulence. This review explores known and newly discovered adhesins in Yersinia species, detailing their roles in infection and disease.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Yersiniae are Gram-negative coccobacilli with three main human pathogens: Y. enterocolitica, Y. pseudotuberculosis, and Y. pestis.
  • These bacteria are crucial models for studying infection biology, including immune evasion and the evolution of virulence factors.
  • Pathogenic Yersiniae rely heavily on adhesin molecules for their virulence.

Purpose of the Study:

  • To review the current knowledge of adhesin molecules in Yersiniae.
  • To discuss the functions of these adhesins in the infection process.
  • To highlight newly identified adhesins and their potential roles.

Main Methods:

  • Literature review of existing research on Yersinia adhesins.
  • Analysis of genomic data to identify novel adhesin candidates.
  • Synthesis of functional data regarding adhesin roles in pathogenesis.

Main Results:

  • Established adhesins like Yersinia adhesin A, invasin, and pH 6 antigen are well-characterized.
  • Genomic studies reveal numerous other adhesins in Yersiniae whose functions are under investigation.
  • Adhesins play critical roles in bacterial adhesion and colonization during infection.

Conclusions:

  • Adhesins are essential virulence factors for pathogenic Yersiniae.
  • Further research is needed to elucidate the functions of newly discovered adhesins.
  • Understanding Yersinia adhesins can provide insights into treating plague and gastrointestinal infections.
Keywords:
Bacterial adhesionBiofilmPathogenesisVirulence factorYersinia

More Related Videos

In Vitro Assay of Bacterial Adhesion onto Mammalian Epithelial Cells05:57

In Vitro Assay of Bacterial Adhesion onto Mammalian Epithelial Cells

Published on: May 16, 2011

26.7K
Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth08:36

Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth

Published on: May 31, 2024

1.0K

Related Concept Videos

Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
7.5K
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
1.1K
Fimbriae, Pili, and Axial Filaments01:28

Fimbriae, Pili, and Axial Filaments

Fimbriae and pili are specialized bacterial surface structures that play pivotal roles in adhesion, genetic exchange, and motility. Composed primarily of pilin protein, these hairlike appendages are crucial for bacterial survival and pathogenicity in various environments.Fimbriae: Adhesion and PathogenicityFimbriae are fine, filamentous structures measuring 2–10 nanometers in diameter and are densely distributed on the bacterial cell surface. They facilitate bacterial adhesion to abiotic...
2.9K
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
13
Adhesion01:14

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
45.4K
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
22