Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 22, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
09:11

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

22.7K

MR-targeted TRUS prostate biopsy using local reference augmentation: initial experience.

Wendy J M van de Ven1, Wulphert Venderink2, J P Michiel Sedelaar3

  • 1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. Wendy.vandeVen@radboudumc.nl.

International Urology and Nephrology
|April 13, 2016
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

(Cost-)effectiveness of focal therapy versus radical therapy (standard of care) in the treatment of men with intermediate-risk prostate cancer: study protocol for the ENFORCE focal randomised controlled trial.

BMJ open·2026
Same author

A nationwide histopathology study reflecting the impact of the introduction of MRI in the diagnostic trajectory of prostate cancer in routine clinical care.

Prostate cancer and prostatic diseases·2026
Same author

Evaluating an AI-driven Triaging Workflow for MRI-based Clinically Significant Prostate Cancer Diagnosis: A Simulation Study.

Radiology. Imaging cancer·2026
Same author

[<sup>177</sup>Lu]-PSMA-617-PSMA-617 in oligometastatic hormone sensitive prostate cancer (BULLSEYE): an open-label, randomised, phase 2 study.

The Lancet. Oncology·2026
Same author

Value of the Acuros reconstruction CBCT algorithm for conventional (non-HyperSight) Ethos systems.

Zeitschrift fur medizinische Physik·2026
Same author

Extending Current Guideline-recommended Prostate-specific Antigen Density Thresholds for Improving Benefit/Harm Balance in Risk-based Magnetic Resonance Imaging-directed Prostate Cancer Diagnosis, from the Community-based Multicentre MR-PROPER Study.

European urology oncology·2025

This study shows that MR-targeted prostate biopsy with local reference augmentation is effective for detecting prostate cancer, particularly for larger suspicious lesions. For smaller or less suspicious lesions, in-bore MR-guided biopsy is recommended.

Area of Science:

  • Urology
  • Radiology
  • Oncology

Background:

  • Prostate cancer diagnosis often relies on biopsies.
  • Magnetic Resonance Imaging (MRI) improves lesion detection.
  • Transrectal Ultrasound (TRUS) guided biopsy is standard, but fusion techniques enhance accuracy.

Purpose of the Study:

  • To evaluate MR-targeted TRUS prostate biopsy using a novel local reference augmentation method.
  • To assess the feasibility and cancer detection rate of this technique.

Main Methods:

  • Tracker-based MR-TRUS fusion with local reference augmentation was employed.
  • Multi-parametric MRI (mpMRI) evaluated lesions using PIRADS classification.
  • Biopsies targeted suspicious lesions identified on mpMRI, recording lesion characteristics and fusion visibility.
Keywords:
BiopsyMR–US fusionPIRADSProstate cancer

More Related Videos

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
06:08

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

1.9K
Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
05:35

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

2.1K

Related Experiment Videos

Last Updated: Mar 22, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
09:11

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

22.7K
A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
06:08

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

1.9K
Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
05:35

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

2.1K

Main Results:

  • The study included 23 patients with 25 MR-suspicious lesions.
  • The overall cancer detection rate was 64% (Gleason score ≥6).
  • Lesion visibility on TRUS after fusion was 88%, with detection rates increasing for larger lesions (>10 mm).

Conclusions:

  • MR-TRUS fusion biopsy with local reference augmentation is feasible and effective.
  • This method is particularly beneficial for larger lesions (≥10 mm) or PIRADS 5 lesions.
  • In-bore MR-guided biopsy is suggested for lesions not meeting these criteria.