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Updated: Mar 22, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy
J M Pitt1, A Marabelle2, A Eggermont3
1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), Villejuif INSERM Unit U1015, Villejuif Faculté de Médecine, Université Paris Sud, Université Paris-Saclay, Le Kremlin Bicêtre Gustave Roussy Cancer Campus, Villejuif Cedex.
Abstract:
The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of cancer development to the concept of a complex tumor ecosystem that supports tumor growth and metastatic dissemination. Accordingly, novel targets within the TME have been uncovered that can help direct and improve the actions of various cancer therapies, notably immunotherapies that work by potentiating host antitumor immune responses. Here, we review the composition of the TME, how this attenuates immunosurveillance, and discuss existing and potential strategies aimed at targeting cellular and molecular TME components.
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