Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

733
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
733
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

652
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
652

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacogenomic Profiling of Voriconazole Enables Predicting Its Toxicity in Pediatric Leukemia and Hematopoietic Stem Cell Transplant Recipients-A Prospective Study From North India.

Journal of clinical pharmacology·2026
Same author

Partial Recovery of Anosmia Since Childhood With Acquired Parosmia: Mechanistic Insights and Therapeutic Implications-A Case Report.

Case reports in otolaryngology·2026
Same author

The Paradigms and Paradoxes of Sigma Metrics in the Analytical Phase of the Medical Diagnostic Laboratory.

Indian journal of clinical biochemistry : IJCB·2026
Same author

The Utilization of Artificial Intelligence by Pediatric Otolaryngology Surgeons in Professional Practice.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale·2026
Same author

Validity and Reliability of the French Olfactory Disorders Questionnaire-10.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale·2025
Same author

A guide to conducting systematic reviews of clinical laboratory tests.

Clinical chemistry and laboratory medicine·2023
Same journal

Neuroprotective Efficacy of Silymarin against Oxidative Stress, Inflammation, and Structural Changes Mediated by Arsenic-induced Toxicity in Rats.

Indian journal of clinical biochemistry : IJCB·2026
Same journal

Validation of New Micro-spectrophotometric Method to Determine Diamine Oxidase Activity in Serum.

Indian journal of clinical biochemistry : IJCB·2026
Same journal

Attitudes of Algorithms: An Exploration of the Ethics of CRISPR Cas9 through the Lens of ChatGPT.

Indian journal of clinical biochemistry : IJCB·2026
Same journal

Pharmacometabolomic Modulation of Biomarkers and Analytical Challenges in GLP-1 Receptor Agonist Therapy.

Indian journal of clinical biochemistry : IJCB·2026
Same journal

Zerumbone Induces Apoptosis and Inhibits Migration of A2058 Melanoma stem-like Cells by Producing Reactive Oxygen Species, Causing G2/M Cell Cycle Arrest, and Controlling the Expression of Genes Linked to Metastasis.

Indian journal of clinical biochemistry : IJCB·2026
Same journal

Elevated Oxidized LDL Level is Associated with Systematic Coronary Risk Evaluation (SCORE2) High-Risk Prediction Algorithm: A Preliminary Study.

Indian journal of clinical biochemistry : IJCB·2026
See all related articles

Related Experiment Video

Updated: Mar 22, 2026

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
07:07

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

11.1K

Hyperhomocysteinemia, MMPs and Cochlear Function: A Short Review.

Seema Bhargava1, Meghaa Shanta Bhargava2, Eishaan Kamta Bhargava3

  • 1Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, India.

Indian Journal of Clinical Biochemistry : IJCB
|April 13, 2016
PubMed
Summary
This summary is machine-generated.

Hyperhomocysteinemia damages the inner ear by altering matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Targeting these MMPs/TIMPs may prevent hearing loss from hyperhomocysteinemia, infections, or ototoxic drugs.

Keywords:
CochleaHearing lossHyperhomocysteinemiaMMPsTIMPs

More Related Videos

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
09:54

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

12.8K
Cochlear Surface Preparation in the Adult Mouse
09:51

Cochlear Surface Preparation in the Adult Mouse

Published on: November 6, 2019

17.8K

Related Experiment Videos

Last Updated: Mar 22, 2026

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
07:07

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

11.1K
Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
09:54

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

12.8K
Cochlear Surface Preparation in the Adult Mouse
09:51

Cochlear Surface Preparation in the Adult Mouse

Published on: November 6, 2019

17.8K

Area of Science:

  • Oto-science
  • Biochemistry
  • Pathology

Background:

  • Hyperhomocysteinemia (HHCY) is linked to cochlear microvasculature and epithelial cell damage.
  • HHCY alters the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in the cochlea.

Purpose of the Study:

  • To investigate the role of MMPs and TIMPs in HHCY-induced ototoxicity.
  • To explore the potential for MMP inhibition in preventing hearing loss.

Main Methods:

  • Analysis of MMP and TIMP expression in the cochlea under HHCY conditions.
  • Comparative study of pathological mechanisms in HHCY, infections, and ototoxicity.

Main Results:

  • HHCY significantly alters the balance of MMPs and TIMPs within the cochlea.
  • The findings suggest a common pathway for cochlear damage in HHCY, infections, and ototoxic drug exposure.

Conclusions:

  • Determining optimal MMP and TIMP concentrations is crucial for mitigating HHCY-related hearing loss.
  • MMP inhibitors show promise in preventing cochlear damage caused by HHCY, infections, and ototoxic agents.