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Published on: February 21, 2016
Hyperhomocysteinemia, MMPs and Cochlear Function: A Short Review
Seema Bhargava1, Meghaa Shanta Bhargava2, Eishaan Kamta Bhargava3
1Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, India.
Abstract:
Hyperhomocysteinemia (HHCY) has been demonstrated to affect cochlear microvasculature as well as cochlear epithelial cells directly, with a resultant alteration of the expression of matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs). Hence, ascertaining the optimum concentration of MMPs and TIMPs in the cochlea could help to inhibit hearing loss due to HHCY by the administration of appropriate MMP inhibitors, Since infections/inflammations as well as ototoxic antibiotics have a similar mechanism of otic pathology, the cochlear damage they cause could also be similarly prevented.
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