Related Experiment Video
Updated: Mar 22, 2026

04:37
Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
1.4K
Phaeohyphomycosis infection in the knee
David Sadigursky1, Luisa Nogueira E Ferreira1, Liz Moreno de Oliveira Corrêa1
1Hospital COT, Salvador, BA, Brazil.
Revista Brasileira De Ortopedia
|April 13, 2016
Summary
Phaeohyphomycosis, a fungal infection, rarely affects large joints. This case report details a successful itraconazole treatment for knee phaeohyphomycosis in an elderly patient without immunosuppression.
Area of Science:
- Mycology
- Infectious Diseases
- Orthopedics
Background:
- Phaeohyphomycosis, typically caused by cutaneous fungi, rarely involves large joints.
- Most reported cases occur in immunosuppressed individuals.
Observation:
- A case of phaeohyphomycosis in the left knee of an elderly, non-immunosuppressed individual presented with anterior knee pain and swelling.
- Initial symptoms mimicked suprapatellar bursitis and did not respond to nonsteroidal anti-inflammatory drugs.
- Surgical resection of the suprapatellar bursa and quadriceps tendon was performed.
Findings:
- Anatomopathological examination and culturing confirmed phaeohyphomycosis.
- Treatment with itraconazole (200 mg/day for six weeks) resulted in complete symptom remission.
- The patient remained asymptomatic with normal physical examination after one year of follow-up.
Implications:
- This is the first reported case of phaeohyphomycosis in the suprapatellar region of the knee.
- Highlights the possibility of phaeohyphomycosis in non-immunosuppressed individuals presenting with knee infections.
- Suggests considering phaeohyphomycosis in recalcitrant knee infections, particularly involving the suprapatellar bursa.
Related Concept Videos
Fungal Group Zygomycota
2.0K
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
2.0K
Knee Joint
3.7K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
3.7K
Fungal Phylum Microsporidia
690
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
690
Bones of the Lower Limb: Femur and Patella
9.1K
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
9.1K
Fungal Phylum Basidiomycota
1.9K
Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
1.9K
Antifungal Agents
20
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
20

