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Updated: Mar 22, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Total Synthesis of Amphirionin-4
Yusuke Ogura1, Hikaru Sato1, Shigefumi Kuwahara1
1Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University , Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan.
Abstract:
An expeditious enantioselective total synthesis of amphirionin-4, a remarkably potent promoter of the proliferation of ST-2 cells, has been achieved from (±)-(E)-1,4-hexadien-3-ol by an 8-pot sequence that features the Sharpless kinetic resolution, iodoetherification, and the CBS reduction to install the stereocenters, utilization of four one-pot transformations to streamline the synthetic process, and the Stille coupling reaction at nearly the center of the target molecule to complete the total synthesis.
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