Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

652
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
652
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

402
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
402
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

834
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
834

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Early Myocardial Calcification on the Background of Fulminant Lymphocytic-Macrophage Myocarditis].

Kardiologiia·2025
Same author

[Glymphatic system in health and disease: a narrative review].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko·2025
Same author

[Expert consensus on approaches to risk stratification and choice of therapy in patients with inoperable and residual chronic thromboembolic pulmonary hypertension].

Terapevticheskii arkhiv·2025
Same author

[Molecular genetic factors of hemostasis system in assessing the risk of arterial and venous thrombosis in microvascular surgery].

Khirurgiia·2024
Same author

[Management Strategy for Patients With Idiopathic Recurrent Pericarditis. Position Statement of the Experts of the Russian Society оf Cardiology and Eurasian Association of Therapists].

Kardiologiia·2024
Same author

[Long-term goflkicept therapy for patients with idiopathic recurrent pericarditis: results of the interim analysis of an ongoing open-label extension study].

Terapevticheskii arkhiv·2024

Related Experiment Video

Updated: Mar 22, 2026

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

3.5K

[Left ventricular noncompaction: A clinical and morphological study].

L B Mitrofanova1, O M Moiseeva1, D A Khashchevskaya1

  • 1V.A. Almazov Federal Medical Research Center, Saint Petersburg, Russia.

Arkhiv Patologii
|April 13, 2016
PubMed
Summary

Left ventricular noncompaction (LVNC) involves significant noncompacted myocardium and often co-occurs with other cardiomyopathies. Findings suggest hemodynamic and inflammatory factors may influence LVNC development.

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.8K
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

5.1K

Related Experiment Videos

Last Updated: Mar 22, 2026

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

3.5K
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.8K
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

5.1K

Area of Science:

  • Cardiovascular Pathology
  • Histopathology
  • Molecular Cardiology

Context:

  • Left ventricular noncompaction (LVNC) is a rare congenital heart defect characterized by excessive trabeculation.
  • Understanding the diverse morphological spectrum and underlying mechanisms of LVNC is crucial for diagnosis and management.

Purpose:

  • To comprehensively analyze the clinicopathological features of left ventricular noncompaction (LVNC).
  • To investigate the association of LVNC with other cardiac pathologies and potential genetic factors.
  • To correlate magnetic resonance imaging (MRI) findings with morphological data in LVNC patients.

Summary:

  • Analysis of 7 LVNC patient hearts revealed a predominant noncompact layer, myocardial hypertrophy, fibrosis, and endocardial fibroelastosis in most cases.
  • Associated findings included right ventricular hypertrabeculation, myocarditis, lipomatosis, and altered connexin 43 expression.
  • Morphological findings aligned with MRI in 100% of cases, showing overlapping features with restrictive, hypertrophic, and dilated cardiomyopathies.

Impact:

  • This study elucidates the complex histopathological landscape of LVNC, highlighting its frequent coexistence with other cardiomyopathies.
  • The findings suggest that hemodynamic and inflammatory factors may play a significant role in the pathogenesis of the LVNC phenotype.
  • Provides valuable insights for differential diagnosis and understanding the multifactorial etiology of LVNC.