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[Mechanism of "treating heart and brain with same methods" based on data science]
Summary
Traditional Chinese Medicine's "Nao Xin Tong Zhi" (NXTZ) theory treats heart and brain diseases similarly. This study investigates NXTZ's mechanism by analyzing coronary heart disease and cerebral apoplexy, revealing common therapeutic targets.
Area of Science:
- Integrative medicine
- Pharmacology
- Biomedical informatics
Context:
- Traditional Chinese Medicine (TCM) posits a unified treatment approach for cardiovascular and cerebrovascular diseases, known as "Nao Xin Tong Zhi" (NXTZ).
- Clinical evidence supports NXTZ's efficacy, yet its underlying molecular mechanisms remain largely unexplored.
- Coronary heart disease (CHD) and cerebral apoplexy are representative conditions where NXTZ is applied.
Purpose:
- To elucidate the potential mechanism of the NXTZ theory in treating cardiovascular and cerebrovascular diseases.
- To identify common therapeutic targets and pathways shared between CHD and cerebral apoplexy.
- To explore the functional roles of drugs effective for both conditions.
Summary:
- This study integrated diverse biomedical data, including drugs, targets, pathways, and diseases.
- Utilized text mining, biological network analysis, and enrichment analysis to uncover shared features between CHD and cerebral apoplexy.
- Identified potential common mechanisms and drug functions underlying the NXTZ theory.
Impact:
- Provides mechanistic insights into an established TCM theory, bridging traditional knowledge with modern scientific understanding.
- Offers a foundation for developing novel, integrated therapeutic strategies for cardiovascular and cerebrovascular diseases.
- Highlights the potential of computational approaches in deciphering complex traditional medicine principles.
