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A new macrolactin antibiotic from deep sea-derived bacteria Bacillus subtilis B5
Wei Li1, Xi-Xiang Tang2,3, Xia Yan4
1a School of Life Science and Biopharmaceutical , Shenyang Pharmaceutical University , Shenyang , China.
Abstract:
A new macrolactin derivate, 7-O-2'E-butenoyl macrolactin A (1), together with three known macrolactin compounds, macrolactin A (2), 7-O-malonyl macrolactin A (3) and 7-O-succinyl macrolactin A (4), was isolated from the bacterial strain Bacillus subtilis B5, which was isolated from the 3000 m deep sea sediment of the Southwest Pacific Ocean. The structures of the new compounds were assigned by spectroscopic methods including 1-D/2-D NMR and MS analysis techniques. Compounds 1 and 2 demonstrated antifungal activities against tea pathogenic fungi Pestalotiopsis theae and Colletotrichum gloeosporioides.
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