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DVT Management and Outcome Trends, 2001 to 2014
Raquel Morillo1, David Jiménez1, Miguel Ángel Aibar2
1Respiratory Department, Ramón y Cajal Hospital and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
Chest
|April 14, 2016
Summary
Temporal trends show reduced hospital stays and mortality for deep vein thrombosis (DVT) patients. Treatment evolved with decreased low-molecular-weight heparin and increased direct oral anticoagulants, improving outcomes.
Area of Science:
- Vascular Medicine
- Health Services Research
- Epidemiology
Background:
- Evaluating temporal trends in deep vein thrombosis (DVT) treatment is crucial for identifying factors impacting short-term patient outcomes.
- Understanding treatment evolution can guide clinical practice and improve patient management strategies.
Purpose of the Study:
- To assess temporal trends in hospital length of stay and therapeutic interventions for DVT patients.
- To examine changes in risk-adjusted mortality rates (all-cause, PE-related, bleeding-related) within 30 days of DVT diagnosis.
Main Methods:
- Analysis of 26,695 adult DVT patients from the Registro Informatizado de la Enfermedad TromboEmbólica registry (2001-2014).
- Assessment of temporal changes in length of hospital stay, pharmacological, and interventional therapies.
- Evaluation of temporal trends in risk-adjusted 30-day mortality for all causes, pulmonary embolism (PE), and bleeding events.
Main Results:
- Mean hospital stay decreased from 9.0 to 7.6 days (2001-2005 vs. 2010-2014).
- Use of low-molecular-weight heparin declined (98% to 90%), while direct oral anticoagulants increased significantly (0.5% to 13.4%).
- Risk-adjusted 30-day all-cause mortality decreased (3.9% to 2.7%), as did bleeding-related mortality (0.5% to 0.1%).
Conclusions:
- Significant reductions in hospital length of stay for DVT patients were observed.
- A decreasing trend in risk-adjusted all-cause and bleeding-related mortality highlights improved patient outcomes.
- The findings underscore the impact of evolving treatment strategies on DVT management and patient prognosis.
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