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Seesaw of matrix metalloproteinases (MMPs)

Charu Kapoor1, Sharad Vaidya, Vijay Wadhwan

  • 1Department of Oral Pathology and Microbiology, Bhojia Dental College, Baddi, Solan, India.

Journal of Cancer Research and Therapeutics
|April 14, 2016
PubMed

Insights

Human matrix metalloproteinases (MMPs) are key proteases in cancer progression and metastasis. This review details MMPs and their therapeutic potential as inhibitors (MMPIs) for cancer treatment.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Human matrix metalloproteinases (MMPs) are a family of proteases regulating extracellular matrix (ECM) turnover.
  • MMPs and their inhibitors are crucial in tumor progression and metastasis via ECM degradation.

Purpose of the Study:

  • To provide a comprehensive review of matrix metalloproteinases (MMPs).
  • To discuss the therapeutic perspectives of MMP inhibitors (MMPIs) in cancer intervention.

Main Methods:

  • Literature review of MMPs.
  • Analysis of therapeutic strategies involving MMPIs in cancer.

Main Results:

  • MMPs are tightly regulated enzymes involved in ECM degradation.
  • MMP inhibitors (MMPIs) represent a developing therapeutic strategy for cancer.

Conclusions:

  • Matrix metalloproteinases play a significant role in cancer.
  • Targeting MMPs with inhibitors offers potential for novel cancer therapies.

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