Acute high-intensity interval rowing increases thrombin generation in healthy men.
Matthew J Sedgwick1,2, Matthew Thompson1, Jack Garnham1
1School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK.
European Journal of Applied Physiology
|April 14, 2016
Summary
High-intensity exercise acutely increases thrombin generation, a marker of blood coagulation, but this effect is temporary. Triacylglycerol levels were lower after exercise, suggesting potential cardiovascular benefits.
Area of Science:
- Exercise Physiology
- Cardiovascular Health
- Hemostasis
Background:
- High-intensity exercise offers health benefits but may transiently elevate cardiovascular event risk.
- This risk is linked to thrombotic changes, increased blood coagulation, and thrombin formation.
Purpose of the Study:
- To investigate the acute effects of high-intensity exercise on plasma thrombin generation.
- To examine the impact of high-intensity exercise on triacylglycerol concentrations.
Main Methods:
- Sixteen healthy men underwent a high-intensity rowing exercise protocol or a rest control.
- Plasma thrombin generation was measured pre- and post-intervention on day 1.
- On day 2, postprandial thrombin generation and triacylglycerol levels were assessed after a meal.
Main Results:
- High-intensity exercise significantly increased markers of thrombin generation (lag time, peak thrombin, endogenous thrombin potential).
- These exercise-induced changes in thrombin generation were not present 16-24 hours later.
- Postprandial triacylglycerol concentrations were reduced following the exercise bout.
Conclusions:
- An acute session of high-intensity interval rowing temporarily enhances plasma thrombin generation.
- The observed pro-thrombotic changes resolve within 16-24 hours post-exercise.
- High-intensity exercise may favorably impact postprandial lipid metabolism.
Related Concept Videos
01:20Exercise and Cardiovascular Response
4.9K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.9K
01:17Exercise and Cardiac Output
2.5K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
2.5K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
2.3K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.3K
01:29Venous Thrombosis III: Interprofessional Care
459
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
459
01:30Venous Thrombosis I: Introduction
663
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
663
01:24Muscle Recovery and Fatigue
4.8K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.8K