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Lethal extrapulmonary mycobacteriosis.

S Kos1, J Důra, J Jirásek

  • 1Department of Tuberculosis and Respiratory Diseases, Faculty Hospital, Plzen, Czechoslovakia.

The European Respiratory Journal
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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A previously healthy man died from disseminated extrapulmonary mycobacteriosis caused by Mycobacterium kansasii. This rare condition rapidly affected multiple organs without lung involvement.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pathology

Background:

  • Tuberculosis (TB) typically affects the lungs, but extrapulmonary TB can occur.
  • Mycobacterium kansasii is an atypical mycobacterium that can cause disease in humans.
  • Disseminated extrapulmonary mycobacteriosis is a rare and severe manifestation of mycobacterial infection.

Observation:

  • A 60-year-old man presented with fever, rash, leukopenia, and gastrointestinal mycosis.
  • Despite prompt medical treatment, the patient experienced rapid deterioration and died within six weeks.
  • Autopsy revealed disseminated tuberculosis in lymph nodes, liver, spleen, and bone marrow, confirmed by acid-fast bacilli smears.

Findings:

  • Bacteriological examination isolated Mycobacterium kansasii from lymph node and spleen tissue.

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  • Histological examination confirmed disseminated tuberculosis but found no evidence of primary lung tuberculosis.
  • The clinical presentation and autopsy findings led to a diagnosis of generalized extrapulmonary mycobacteriosis.

    • Implications:

    • This case highlights the potential for Mycobacterium kansasii to cause severe, rapidly progressive disseminated extrapulmonary disease.
    • It underscores the importance of considering atypical mycobacterial infections in immunocompetent individuals presenting with disseminated disease, even without apparent lung involvement.
    • Early diagnosis and appropriate antimicrobial therapy are crucial for managing this rare but potentially fatal condition.