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Updated: Mar 22, 2026

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
Published on: October 31, 2012
Adipose stromal cells improve healing of vocal fold scar: Morphological and functional evidences
Guillaume de Bonnecaze1,2,3, Benoit Chaput1,2,4,5,6, Virginie Woisard3
1CNRS UMR5273 STROMALab, University of Toulouse, Toulouse Cedex, France.
Objectives/Hypothesis:
Adipose derived stromal cells (ASCs) are abundant and easy to prepare. Such cells may be useful for treating severe vocal disturbance caused by acute vocal fold scars.
Study Design:
Prospective animal experiments with controls.
Methods:
Twenty New-Zealand white rabbits were used in the present study. We evaluated vocal fold healing, with or without injection of autologous ASCs, after acute scarring. A defined lesion was created and the ASCs were immediately injected. Vocal fold regeneration was evaluated histomorphometrically and via viscoelastic analysis using an electrodynamic shaker.
Results:
Six weeks after ASC injection, vocal folds exhibited significantly less inflammation than control folds (P < 0.005). In addition, hypertrophy of the lamina propria and fibrosis were significantly reduced upon ASC injection (P < 0.02). The decrease in viscoelastic parameters was less important in the ASC injected group compared to the noninjected group (P = 0.08).
Conclusion:
Injection of autologous ASCs improved vocal fold healing in our preclinical model. Further studies are needed, but this method may be useful in humans.
Level Of Evidence:
NA. Laryngoscope, 126:E278-E285, 2016.
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