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Updated: Mar 22, 2026

Novel Sequence Discovery by Subtractive Genomics
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ISEA: Iterative Seed-Extension Algorithm for De Novo Assembly Using Paired-End Information and Insert Size

Min Li, Zhongxiang Liao, Yiming He

    IEEE/ACM Transactions on Computational Biology and Bioinformatics
    |April 15, 2016
    PubMed
    Summary

    The new iterative seed-extension algorithm (ISEA) improves de novo assembly by correcting errors and handling repeats using paired-end information. This results in more contiguous, complete, and accurate DNA sequence scaffolds.

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