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Reference values for resistance and compliance based on the single occlusion technique in healthy infants from
Jianfeng Huang1, Hao Zhang1, Mingzhi Zhang1
11 Respiratory Department, Children's Hospital of FuDan University, Shanghai 201102, China ; 2 Respiratory Department, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
Insights
This study provides reference values for respiratory resistance and compliance in healthy infants using the single occlusion technique (SOT). These findings aid in assessing normal respiratory mechanics in infants.
Area of Science:
- Pediatric Pulmonology
- Respiratory Physiology
- Infant Health
Background:
- Respiratory diseases significantly impact infant morbidity and mortality.
- Establishing normal respiratory parameters is crucial for early diagnosis and management.
- The single occlusion technique (SOT) is a method for assessing respiratory function.
Purpose of the Study:
- To establish reference values for respiratory resistance (Rrs) and respiratory compliance (Crs) in healthy infants using SOT.
- To provide normative data for infants in Southeast China.
- To develop predictive equations for Rrs and Crs based on infant characteristics.
Main Methods:
- Respiratory resistance and compliance were measured in 205 healthy infants (aged 1-96 weeks) using SOT.
- Infants were grouped by age (1-24, 25-48, 49-72, 73-96 weeks) for analysis.
- Multiple regression analysis was used to develop predictive equations, considering age, length, weight, and BMI, stratified by sex.
Main Results:
- Respiratory resistance (Rrs) declined with increasing infant length.
- Respiratory compliance (Crs) increased with infant growth.
- Median Rrs was 5.04 kPa/L/sec, and mean Crs was 119.52±60.47 mL/kPa.
- Predictive regression equations for Rrs and Crs were successfully derived.
Conclusions:
- Reference values for passive respiratory mechanics were established in healthy Southeast Chinese infants using SOT.
- These data serve as a valuable reference for evaluating the normality of SOT measurements in infants.
- The findings support the clinical utility of SOT in pediatric respiratory assessment.
Background:
Respiratory disease is a major cause of morbidity and mortality in infants and has a large impact on health care. The aim of this study was to present the reference values of resistance and compliance by using a single occlusion technique (SOT) in healthy infants in Southeast China.
Methods:
Respiratory compliance (Crs) and respiratory resistance (Rrs) were measured in healthy infants, aged 1-96 weeks, by using SOT in the Children's Hospital of FuDan University (Shanghai, China). For comparison, the infants were grouped by age as follows: 1-24, 25-48, 49-72 and 73-96 weeks. Multiple regression analysis was performed using age, length, weight, and body mass index (BMI) as the independent variables to obtain predictive equations, separated according to sex.
Results:
We measured 205 healthy infants from birth up to 96 weeks of age (112 boys, 93 girls). Height and weight increased significantly with age. The Rrs declined with length, whereas the Crs increased. The median Rrs was 5.04 kPa/L/sec (range, 3.73-6.82 kPa/L/sec), and the mean Crs was 119.52±60.47 mL/kPa. Regression equations for Rrs and Crs were obtained.
Conclusions:
We obtained reference values for passive respiratory mechanics by using SOT in healthy infants from Southeast China. These data provide references for assessing the normality of SOT measurements in infants.
