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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
34.2K
[Molecular biological predictors for kidney cancer]
S V Vtorushin1, V O Tarakanova2, M V Zavyalova1
1Tomsk Cancer Research Institute; Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia.
Arkhiv Patologii
|April 15, 2016
Summary
This study reviews molecular predictors for renal cell carcinoma (RCC). Key markers like Bcl-2, Beclin 1, Annexin A2, SAM68, EpCAM, and PD-L1 show potential for prognosis and treatment response in RCC patients.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Context:
- Renal cell carcinoma (RCC) is a significant health concern with a need for improved prognostic and predictive markers.
- Current research focuses on identifying molecular indicators within tumor tissues and cell death pathways to better understand RCC progression and treatment outcomes.
Purpose:
- To review and synthesize current literature on potential molecular predictors for renal cell carcinoma (RCC).
- To evaluate the role of specific proteins involved in apoptosis, autophagy, cell proliferation, adhesion, and immune response as potential biomarkers for RCC.
Summary:
- Bcl-2, an apoptosis inhibitor, shows high expression correlating with a favorable RCC prognosis.
- Beclin 1, an autophagy indicator, presents a dual role: its inactivation increases tumorigenesis risk, while high expression in tumors reduces chemotherapy efficacy.
- Overexpression of Annexin A2 promotes RCC growth and invasion, while SAM68 overexpression is linked to lower survival rates.
- Epithelial cell adhesion molecule (EpCAM) overexpression is associated with longer survival in patients without metastases.
- High PD-L1 expression on cell membranes is a potential marker for effective immunotherapy in RCC.
Impact:
- Identifies key molecular markers that could refine RCC prognostication and guide therapeutic strategies.
- Highlights the complex roles of apoptosis and autophagy markers in RCC, influencing treatment decisions.
- Provides insights into potential targets for novel RCC therapies, including immunotherapy and chemotherapy optimization.
