Related Experiment Video
Updated: Mar 22, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Jacob's disease: Report of a case
Dong-Whan Shin1, Ji-Eun Kim2, Hee-Sun Kim3
1a Department of Oral and Maxillofacial Surgery, Section of Dentistry , Seoul Metropolitan Government - Seoul National University Boramae Medical Center , Seoul , Republic of Korea.
Jacob's disease (JD) with intraosseous lipoma (IOL) is rare. Surgical intervention successfully resolved limited mouth opening caused by this unique mandibular condition.
Area of Science:
- Oral and Maxillofacial Surgery
- Pathology
- Radiology
Background:
- Jacob's disease (JD) involves pseudojoint formation causing limited mouth opening (MOL).
- Intraosseous lipoma (IOL) is rare in the mandible, typically occurring in long bones.
Observation:
- A 39-year-old female presented with MOL due to a coexisting JD and mandibular IOL.
- MRI revealed a large, fat-intensity mass.
- Histopathology confirmed a degenerated lipomatous tumor with cartilaginous changes.
Findings:
- Surgical resection via a combined approach successfully removed the mass.
- The patient experienced complete resolution of MOL post-surgery.
Implications:
- This case highlights the importance of considering rare coexisting pathologies in the mandible.
- Effective surgical management can restore function in complex cases of JD and IOL.
More Related Videos
07:50A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
10:23Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
Published on: September 8, 2023
Related Concept Videos
Sex-linked Disorders
Aneurysm II: Clinical Manifestations and Diagnostic Studies
General Case of Eccentric Axial Loading
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Sex Linked Disorders
Case Studies