Related Experiment Video
Updated: Mar 22, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
Birth Cohorts Analysis of Adolescent Cigarette Smoking and Subsequent Marijuana and Cocaine Use
Katherine M Keyes1, Ava Hamilton1, Denise B Kandel1
1Katherine M. Keyes and Ava Hamilton are with the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY. Denise B. Kandel is with the College of Physicians and Surgeons, Columbia University, and the New York State Psychiatric Institute, New York.
Objectives:
To examine whether the drug behavior of adults from different birth cohorts is shaped by adolescent drug experiences and whether adult prevalence of marijuana and cocaine use depends on adolescent cigarette or alcohol use prevalence.
Methods:
We analyzed 18 birth cohorts comprising 8th, 10th, and 12th graders, sampled from 1991 to 2008, from Monitoring the Future, an annual nationally representative cross-sectional survey of high school students in the United States (n = 864 443).
Results:
Within cohorts, lifetime rates of 8th and 10th grade cigarette use were significantly associated with subsequent lifetime rates of marijuana and cocaine use, controlling for trends in use and social norms toward drug use. Each percent increase (or decrease) in 8th and 10th grade smoking was associated with an 8% increase (or decrease) in prevalence of later marijuana use and 14% to 23% increase (or decrease) in prevalence of later cocaine use. Relationships were consistent by gender and race/ethnicity.
Conclusions:
Prevalences of smoking in 8th and 10th grade and of marijuana and cocaine use in 12th grade are associated. Public health campaigns should focus on early stages of adolescence, when drug use habits are forming.
Related Concept Videos
Statistical Methods for Analyzing Epidemiological Data
Longitudinal Research
Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Cross-Sectional Research
Cognitive Development During Adolescence

