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Updated: Mar 22, 2026
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
Published on: October 17, 2016
Novel biodegradable star-shaped polylactide scaffolds for bone regeneration fabricated by two-photon polymerization
Peter Timashev1, Daria Kuznetsova2, Anastasia Koroleva3
1Institute of Photonic Technologies, Research Centrer of Crystallography and Photonics RAS, 108840, Troitsk, Moscow, Russia.
Aim:
To assess the properties of 3D biodegradable scaffolds fabricated from novel star-shaped poly(D,L-lactide) (SSL) materials for bone tissue regeneration.
Materials & Methods:
The SSL polymer was synthesized using an optimized synthetic procedure and applied for scaffold fabrication by the two-photon polymerization technique. The osteogenic differentiation was controlled using human adipose-derived stem cells cultured for 28 days. The SSL scaffolds with or without murine MSCs were implanted into the cranial bone of C57/Bl6 mice.
Results:
The SSL scaffolds supported differentiation of human adipose-derived stem cells toward the osteogenic lineage in vitro. The SSL scaffolds with murine MSCs enhanced the mineralized tissue formation.
Conclusion:
The SSL scaffolds provide a beneficial microenvironment for the osteogenic MSCs' differentiation in vitro and support de novo bone formation in vivo.
