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Impression Cytology of the Lid Wiper Area

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Altered Bulbar Conjunctival Microcirculation in Response to Contact Lens Wear.

Wan Chen¹, Zhe Xu, Hong Jiang

¹Department of Ophthalmology (W.C.), Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of Ophthalmology (W.C., Z.X., H.J., J.Z., J.W.), Bascom Palmer Eye Institute, University of Miami, Miami, FL; School of Ophthalmology and Optometry (Z.X.), Wenzhou Medical College, Wenzhou, Zhejiang, China; Department of Neurology (H.J.), University of Miami, Miami, FL; Department of Ophthalmology (J.Z.), Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, China; and Krieger School of Arts and Sciences (L.W.), Johns Hopkins University, Baltimore, MA.

Eye & Contact Lens

|April 15, 2016

Summary

Contact lens wear increases blood flow velocity in bulbar conjunctival microvasculature. This study used a functional slit-lamp biomicroscope to measure these changes in vessel diameter and flow.

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Area of Science:

Ophthalmology
Microcirculation Research
Biomedical Optics

Background:

Contact lens wear can impact the ocular surface microvasculature.
Understanding these microvascular changes is crucial for contact lens safety and comfort.

Purpose of the Study:

To quantify blood flow velocities and vessel diameters in the bulbar conjunctiva.
To characterize the microvascular response to 6-hour contact lens wear.

Main Methods:

A functional slit-lamp biomicroscope (FSLB) was employed.
Temporal bulbar conjunctiva of 22 healthy subjects were imaged before and after lens wear.
Venule diameters and blood flow velocities were measured.

Main Results:

Average blood flow velocity increased significantly (P<0.001) after 6 hours of contact lens wear.
Increased velocity correlated with increased vessel diameter across all measured ranges (r=0.826 to 0.925, P<0.05).

Conclusions:

Contact lens wear induces an increase in bulbar conjunctival blood flow velocity.
The FSLB is effective for characterizing microvascular responses to contact lens wear.