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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
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Diabetes: Management and Pharmacotherapy01:15

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Diabetes Mellitus: Overview and Type I Subtype01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Carbohydrate Metabolism01:36

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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
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Insulin: Dosing Regimen and Adverse Effects

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Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
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Type 2 Diabetes Medication Review.

James J Sterrett1, Scott Bragg1, Charles Wayne Weart1

  • 1South Carolina College of Pharmacy, Charleston, South Carolina.

The American Journal of the Medical Sciences
|April 16, 2016
PubMed
Summary
This summary is machine-generated.

Choosing the right medication for type 2 diabetes involves balancing risks and benefits. This review guides healthcare providers in selecting the best glucose-lowering drugs based on patient-specific factors and evidence.

Keywords:
MedicationsNewer drugsPharmacotherapySystemic reviewType 2 diabetes

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Internal Medicine

Background:

  • Type 2 diabetes management involves numerous glucose-lowering medications.
  • Recent FDA approvals have significantly expanded treatment options over the past decade.

Purpose of the Study:

  • To provide an overview of antiglycemic medication classes and specific drugs.
  • To present patient-centered evidence that matters (POEMs) for medication selection.

Main Methods:

  • Literature search focused on patient-oriented evidence that matters (POEMs).

Main Results:

  • Medication selection requires careful consideration of risks, benefits, and individual patient factors.
  • Key factors include cardiovascular outcomes, A1c goals, side effects, comorbidities, and cost.

Conclusions:

  • The paper offers a comprehensive comparison of antiglycemic agents.
  • Data covers safety, tolerability, efficacy, cost, and ease of use for patient-centered decision-making.