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Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac
Mariann Gyöngyösi1, Wojciech Wojakowski2, Eliano P Navarese2
1From the Department of Cardiology, Medical University of Vienna, Vienna, Austria (M.G.); 3rd Department of Cardiology, Medical University of Silesia, Katowice, Poland (W.W.); Division of Cardiology, Pulmonology and Vascular Medicine, Department of Internal Medicine, Heinrich-Heine-University, Düsseldorf, Germany (E.P.N.); Systematic Investigation and Research on Interventions and Outcomes (SIRIO) MEDICINE Research Network (E.P.N.); and CCTRN Data Coordinating Center, University of Texas Houston School of Public Health, Houston (L.À.M.). mariann.gyongyosi@meduniwien.ac.at.
Abstract:
In contrast to multiple publication-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myocardial infarction, a recently published meta-analysis based on individual patient data reported no effect of cell therapy on left ventricular function or clinical outcome. A comprehensive review of the data collection, statistics, and the overall principles of meta-analyses provides further clarification and explanation for this controversy. The advantages and pitfalls of different types of meta-analyses are reviewed here. Each meta-analysis approach has a place when pivotal clinical trials are lacking and sheds light on the magnitude of the treatment in a complex healthcare field.
