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Updated: Jan 19, 2026
Behavioral Tests to Assess Executive Functions in Children with ASD
Published on: April 29, 2023
Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors
Laura Mandelli1, Elena Toscano1, Stefano Porcelli1
1Department of Biomedical and Neuromotor Sciences, Institute of Psychiatry, University of Bologna, Bologna, Italy.
Abstract:
In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to stressful life events (SLEs). Eight polymorphisms (SNPs) were tested in 94 Schizophreniainpatients and 176 healthy controls. Schizophrenia patients were also evaluated for SLEs in different life periods. None of the SNPs showed association with schizophrenia. Nevertheless, when crossing genetic variants with childhood SLEs, we could observe trends of interaction with age of onset. Though several limitations, our results support a protective role of ST8SIA2 in individuals exposed to moderate childhood stress.
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