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Updated: Mar 22, 2026
Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
Published on: April 15, 2022
Data for accelerated degradation of calcium phosphate surface-coated polycaprolactone and polycaprolactone/bioactive
Patrina S P Poh1, Dietmar W Hutmacher2, Boris M Holzapfel3
1Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, 4059 Brisbane, Australia; Department of Experimental Trauma Surgery, Klinikum Rechts der Isar, Technical University Munich, Ismaninger 22, 81675 Munich, Germany.
Abstract:
Polycaprolactone (PCL)-based composite scaffolds containing 50 wt% of 45S5 bioactive glass (45S5) or strontium-substituted bioactive glass (SrBG) particles were fabricated into scaffolds using melt-extrusion based additive manufacturing technique. Additionally, the PCL scaffolds were surface coated with a layer of calcium phosphate (CaP). For a comparison of the scaffold degradation, the scaffolds were then subjected to in vitro accelerated degradation by immersion in 5 M sodium hydroxide (NaOH) solution for up to 7 days. The scaffold׳s morphology was observed by means of SEM imaging and scaffold mass loss was recorded over the experimental period.
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