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Corticosteroids decrease airway hyperresponsiveness in the Basenji-Greyhound dog model of asthma.

M J Darowski1, V M Hannon, C A Hirshman

  • 1Department of Anesthesiology, Johns Hopkins University, Baltimore, Maryland 21205.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 1, 1989
PubMed
Summary
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Methylprednisolone oral treatment reduced airway hyperresponsiveness in dogs by decreasing eosinophils. This suggests methylprednisolone interferes with inflammation, impacting airway reactivity.

Area of Science:

  • Veterinary Pharmacology
  • Pulmonary Physiology
  • Immunology

Background:

  • Airway hyperresponsiveness is a key feature of asthma.
  • Eosinophils play a significant role in airway inflammation and hyperresponsiveness.
  • Corticosteroids are commonly used to manage inflammatory airway diseases.

Purpose of the Study:

  • To investigate the effect of methylprednisolone on airway hyperresponsiveness in Basenji-Greyhound dogs.
  • To determine if methylprednisolone reduces airway inflammation, specifically eosinophil counts.
  • To explore the mechanism underlying methylprednisolone's effect on airway reactivity.

Main Methods:

  • Oral methylprednisolone or placebo treatment for 6 weeks in dogs.
  • Assessment of airway responsiveness to methacholine and citric acid.

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  • Bronchoalveolar lavage and blood eosinophil counts analyzed.

    • Main Results:

    • Methylprednisolone abolished citric acid-induced bronchoconstriction and reduced methacholine responsiveness.
    • No significant changes in baseline airway resistance or dynamic compliance were observed.
    • Methylprednisolone markedly reduced eosinophils in bronchoalveolar lavage fluid and blood.

    Conclusions:

    • Methylprednisolone effectively reduces airway hyperresponsiveness in this canine model.
    • The anti-inflammatory effect, particularly the reduction of eosinophils, is a likely mechanism.
    • Findings suggest methylprednisolone's potential in managing inflammatory airway conditions.