Antioxidant farnesylated hydroquinones from Ganoderma capense

Area of Science:

• Natural Product Chemistry
• Medicinal Mycology

Background:

• Ganoderma species are known for producing bioactive compounds.
• Aromatic meroterpenoids represent a class of natural products with diverse biological activities.

Purpose of the Study:

• To isolate and characterize aromatic meroterpenoids from Ganoderma capense.
• To evaluate the antioxidant potential of the isolated compounds.

Main Methods:

• Phytochemical investigation of Ganoderma capense fruiting bodies.
• Structure elucidation using extensive spectroscopic techniques and Mosher's method.
• Antioxidant activity assessment via DPPH radical scavenging assay.

Main Results:

• Eight aromatic meroterpenoids (1-8) were isolated.
• Two new compounds, Ganocapensins A (1) and B (2), featuring thirteen- and fourteen-membered ether rings, were identified.
• All isolated compounds exhibited significant antioxidant effects, with IC50 values between 6.00±0.11 and 8.20±0.30 μg/ml.

Conclusions:

• Ganoderma capense is a source of novel aromatic meroterpenoids.
• The isolated meroterpenoids possess notable antioxidant properties, suggesting potential therapeutic applications.