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Colchicine for children with pericarditis: systematic review of clinical studies

Samer Alabed1, Giordano Pérez-Gaxiola2, Amanda Burls3

  • 1Academic Radiology Registrar at Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Archives of Disease in Childhood
|April 17, 2016
PubMed

Insights

Evidence for colchicine in pediatric pericarditis is limited. This systematic review found insufficient data to support or refute its use in children, highlighting the need for randomized controlled trials (RCTs).

Area of Science:

  • Pediatric Cardiology
  • Pharmacology
  • Systematic Reviews

Background:

  • Pericarditis is inflammation of the pericardium, a condition that can affect children.
  • Colchicine is an established treatment for pericarditis in adults.
  • The use of colchicine in pediatric patients with pericarditis is not routine due to limited evidence.

Purpose of the Study:

  • To systematically review existing evidence on the efficacy and safety of colchicine for treating pericarditis in children.
  • To identify the current state of research regarding colchicine's role in pediatric pericarditis management.

Main Methods:

  • A systematic review of observational and experimental human studies was conducted.
  • Searches were performed across multiple databases (Cochrane Central, Medline, EMBASE, LILACS) up to June 2015.
  • Data extraction and quality assessment were performed by two authors using the Cochrane risk of bias tool for non-randomised trials.

Main Results:

  • The review included 11 studies (2 case series, 9 case reports) involving 86 children with pericarditis.
  • Five articles (74 patients) suggested colchicine may prevent pericarditis recurrences.
  • Six studies (12 patients) indicated colchicine did not prevent recurrences.

Conclusions:

  • No randomized controlled trials (RCTs) were identified in the review.
  • There is insufficient evidence to either support or discourage the use of colchicine in children with pericarditis.
  • Large, double-blind RCTs are necessary to determine the efficacy and safety of colchicine in pediatric pericarditis.
Abstract

Keywords:
colchicinepericarditissystematic review

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