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Coagulation disorders and their cutaneous presentations: Pathophysiology
Yunyoung Chang1, Ganary Dabiri2, Elizabeth Damstetter1
1Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
Journal of the American Academy of Dermatology
|April 18, 2016
Summary
Hypercoagulable states increase thrombosis risk. Dermatologists can identify these conditions through skin symptoms, improving patient outcomes by reducing related morbidity and mortality.
Area of Science:
- Hematology
- Dermatology
- Pathophysiology
Background:
- Hypercoagulable states are inherited or acquired conditions predisposing individuals to thrombosis.
- Understanding these states involves analyzing the complex coagulation cascade.
- Cutaneous manifestations can be early indicators of underlying hypercoagulable conditions.
Purpose of the Study:
- To review the epidemiology and pathophysiology of hypercoagulable states.
- To highlight the critical role of dermatologists in identifying and managing these conditions.
- To provide a foundation for understanding clinical features, diagnostics, and treatment in the accompanying article.
Main Methods:
- Literature review focusing on epidemiology and pathophysiology.
- Analysis of the coagulation cascade in relation to thrombotic events.
- Correlation of dermatological presentations with hypercoagulable states.
Main Results:
- Hypercoagulable states represent a significant risk factor for both venous and arterial thromboses.
- Early recognition of cutaneous symptoms by dermatologists can lead to timely diagnosis.
- Understanding pathophysiology is key to comprehending the predisposition to clot formation.
Conclusions:
- Dermatologists are pivotal in the early diagnosis and management of hypercoagulable states.
- Identifying skin manifestations can significantly reduce patient morbidity and mortality.
- This review provides essential epidemiological and pathophysiological context for hypercoagulable states.
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