Related Experiment Video
Updated: Mar 22, 2026

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics
Published on: September 2, 2020
Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the
Aurelia Vergeade1, Clinton C Bertram2, Alfiya T Bikineyeva3
1Department of Pharmacology, Vanderbilt University Medical Center, 536 Robinson Research Building, Nashville, TN 37232-6602, United States.
Abstract:
Modifications of cardiolipin (CL) levels or compositions are associated with changes in mitochondrial function in a wide range of pathologies. We have made the discovery that acetaminophen remodels CL fatty acids composition from tetralinoleoyl to linoleoyltrioleoyl-CL, a remodeling that is associated with decreased mitochondrial respiration. Our data show that CL remodeling causes a shift in electron entry from complex II to the β-oxidation electron transfer flavoprotein quinone oxidoreductase (ETF/QOR) pathway. These data demonstrate that electron entry in the respiratory chain is regulated by CL fatty acid composition and provide proof-of-concept that pharmacological intervention can be used to modify CL composition.
More Related Videos
Related Concept Videos
Overview of Fatty Acid Metabolism
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
The Inner Mitochondrial Membrane
The Supercomplexes in the Crista Membrane
Mitochondrial Membranes
Mitochondrial Membranes
Lipid Catabolism

