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Subjective and Real Time: Coding Under Different Drug States.

Hugo Sanchez-Castillo1, Kathleen M Taylor2, Ryan D Ward3

  • 1Universidad Nacional Autónoma de México, México.

International Journal of Comparative Psychology
|April 19, 2016
PubMed
Summary
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Dopamine modulation does not change how animals learn time intervals. However, drugs affecting dopamine acutely impact the start of responding during timing tasks.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Pharmacology

Background:

  • Interval timing allows organisms to predict environmental changes and select actions.
  • Dopaminergic system activity is hypothesized to modulate interval timing, with higher dopamine speeding up and lower dopamine slowing down an internal clock.
  • Existing research primarily examines dopamine's effect on established timing performance, not its influence on acquiring temporal control.

Purpose of the Study:

  • To investigate the impact of altered dopamine levels on the acquisition of temporal control.
  • To determine if dopamine modulation affects the initial learning of time intervals.

Main Methods:

  • Thirty male Sprague-Dawley rats were divided into three groups: haloperidol, d-amphetamine, or vehicle.
  • Animals received daily injections 15 minutes before sessions throughout interval training.
Keywords:
AcquisitionHaloperidolMethamphetamineRecallTemporal Information ProcessingTimingdopamine

Related Experiment Videos

  • Training involved a Fixed Interval (FI) 16s schedule followed by a peak procedure with 64s non-reinforced trials.

    • Main Results:

    • Dopamine modulation did not alter the encoding of temporal durations during acquisition.
    • Administration of drugs affecting dopamine acutely impacted the initiation of responding.
    • Post-drug training performance indicated no change in the encoding of time.

    Conclusions:

    • Altering dopamine levels does not impede the fundamental learning of temporal durations.
    • Dopamine influences the immediate execution of timed responses rather than the underlying temporal memory encoding.