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The Effects of Fentanyl on Hepatic Mitochondrial Function

Siamak Djafarzadeh1, Madhusudanarao Vuda, Victor Jeger

  • 1From the *Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland; and †Department of Clinical Research, Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.

Anesthesia and Analgesia
|April 19, 2016
PubMed
Summary

Fentanyl marginally impacts liver cell mitochondrial respiration, an effect blocked by naloxone or 5-HD. This opioid reduces cellular ATP, potentially due to increased energy demands for drug efflux transport.

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