[Reactive arthritis: inflammation or true infection?]

Area of Science:

• Rheumatology
• Infectious Diseases
• Immunology

Context:

• Classical definition of reactive arthritis as aseptic arthritis post-bacterial infection.
• Potential for non-sterile, chronic infections in reactive arthritis.
• Broader classification including post-streptococcal and post-viral arthritis.

Purpose:

• To re-evaluate the definition and understanding of reactive arthritis.
• To explore the role of chronic infections in reactive arthritis.
• To consider long-term antibiotherapy for specific cases.

Summary:

• Reactive arthritis, a form of spondyloarthritis, is triggered by bacterial infections (urogenital/intestinal).
• Contrary to classical views, it may not always be sterile, suggesting chronic infection potential.
• Long-term antibiotic treatment may be indicated for persistent infections.

Impact:

• Challenges the traditional aseptic definition of reactive arthritis.
• Highlights the importance of identifying and treating chronic infections.
• Expands the concept of reactive arthritis to include other post-infectious rheumatic conditions.